Research project funded by the European Research Council (ERC)

PrintMed: Printing personalised medicines on demand

ERC Proof of Concept No. 963914 granted to Prof. Majid Hassanizadeh (Utrecht University). The project is affiliated at the Cluster of Excellence "SimTech". The scientific work is realised at the Department of Hydromechanics and Modelling of Hydrosystems

Project description

Methods of pharmaceutical manufacturing are likely to change dramatically over the coming years. Driven by the knowledge and technology that is already available in other sectors, the processing of drugs into dosage units can be transformed into a “pharmacy-on-demand” process that allows individual dosing, based on criteria relevant for the effective use of the drug in an individual patient. One approach to achieve “pharmacy-on-demand” is the use of inkjet printing technology to deliver an exact dose of drugs on porous substrates. This proof-of-concept project is based on knowledge we acquired during my ERC Advanced Grant project on processes of printing on paper using inkjet printing. We will demonstrate the viability of "printing" highly accurate amounts of a solution containing levothyroxine, prescribed for hypothyroidism, onto a porous tablet. Modelling tools will be combined with cutting-edge characterization technologies to push the understanding of printed drug-containing inklike solutions in porous dosage unit matrices. This project will transfer pharmaceutical formulation and product design of individual dosage forms with the use of inkjet printing technique to the pharmaceutical community. They can work on clinical approval tests of the developed oral dosage forms and move these products toward clinical use. The patients will benefit directly from development of this production technique, because a much more effective and targeted medication can be provided. The next step will be the development of the inkjet printing technique for other personalized medicines such as pain killers for children, hormones, biomacromolecules, psychoactive and anticancer drugs. Individually-dosed medicines will allow for substantial decrease of drug waste and thus overall reduction of medical expenses.

Project leader

Prof. dr. ir. Majid Hassanizadeh

Researcher

Department

LH2

Duration

11/2020 - 04/2022

Funding

Contact

This image shows Majid Hassanizadeh
Prof. dr. ir.

Majid Hassanizadeh

Senior Professor / SFB 1313 Mercator Fellow

This image shows Hamed Aslannejad
Dr. Ir.

Hamed Aslannejad

Academic Staff

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